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A total of three % of Energetic substance is excreted in urine as unchanged Lively substance. Tapentadol is Also metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which can be even further metabolised by conjugation. Hence, Energetic material metabolism mediated by cytochrome P450 syste